Study protocol for a group randomized controlled trial of a classroom-based intervention aimed at preventing early risk factors for drug abuse: integrating effectiveness and implementation research

Abstract Background While a number of preventive interventions delivered within schools have shown both short-term and long-term impact in epidemiologically based randomized field trials, programs are not often sustained with high-quality implementation over time.This study was designed to support two purposes.The first purpose was to test the effe

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The remote allosteric control of Orai channel gating.

Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth.The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered by the Ca2+ sensor Stromal Interaction Molecule (STIM) proteins FOAM CONDITIONER of the endoplasmic r

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